Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Reichardt, Holger, Prof. Dr.

Professor of Experimental Immunology


  • 1989-1994: Studies in Biochemistry at the Universities of Tübingen, Munich and Fribourg/Switzerland
  • 1994-1997: PhD thesis at the German Cancer Research Center and the University of Heidelberg
  • 1997-2001: Junior group leader with Günther Schütz, German Cancer Research Center Heidelberg
  • 2001-2002: Independent group leader, Institute for Virology and Immunobiology, University of Würzburg
  • 2002-2006: Professor of Molecular Immunology, University of Würzburg
  • since 2007: Professor of Experimental Immunology, University of Göttingen



Major Research Interests

Inflammatory diseases such as Multiple Sclerosis, Type I Diabetes mellitus, Asthma and Graft-versus-Host-Disease are major health problems in the western world, often require lifetime medical treatment and may result in permanent disability and early death. Generally, therapy is often unsatisfactory and accompanied by side effects. Therefore our work aims at better understanding the mechanisms underlying traditional and new treatment regimens for chronic inflammatory diseases. First and foremost our approaches concern the mode of action of glucocorticoids, which are still the mainstay of many therapies employed in the clinic. To accomplish our goal, we primarily focus on T lymphocytes and myeloid cells and use a plethora of molecular and immunological techniques, different cell culture systems and a variety of animal models. Since glucocorticoid therapy is accompanied by metabolic side effects, some approaches in the lab also deal with the impact of anti-inflammatory therapies on muscle, liver, bone and the gastrointestinal tract. All our projects are integrated in a dense network of cooperation involving colleagues from allover the world.


Homepage Department/Research Group
http://www.immunologie.uni-goettingen.de


Selected Recent Publications


  • Gayer, F.A., Fichtner, A., Legler, T.J., and Reichardt H.M. (2022). A coculture model mimicking the tumor microenvironment unveils mutual interactions between immune cell subtypes and the human seminoma cell line TCam-2. Cells 11, 885.
  • Bier, J., Steiger, S.M., Reichardt, H.M., and Lühder, F. (2021). Protection of antigen-primed effector T cells from glucocorticoid-induced apoptosis in cell culture and in a mouse model of multiple sclerosis. Frontiers in Immunology 12, 671258.
  • Muzzi, C., Watanabe, N., Twomey, N., Meers, G.K., Reichardt, H.M., Bohnenberger, H., and Reichardt, S.D. (2021). The glucocorticoid receptor in intestinal epithelial cells alleviates colitis and associated colorectal cancer in mice. Cellular and Molecular Gastroenterology and Hepatology 11, 1505-1518.
  • Kaiser, T.K., Khorenko, M., Moussavi, A., Engelke, M., Boretius, S., Feldmann, C., and Reichardt, H.M. (2020). Highly selective organ distribution and cellular uptake of inorganic-organic hybrid nanoparticles customized for the targeted delivery of glucocorticoids. Journal of Controlled Release 319, 360-370.
  • Lodygin, D., Hermann, M., Schweingruber, N., Flügel-Koch, C., Watanabe, T., Schlosser, C., Merlini, A., Körner, H., Chang, H.F., Fischer, H.J., Reichardt, H.M., Zagrebelsky, M., Mollenhauer, B., Kügler, S., Fitzner, D., Frahm, J., Stadelmann, C., Haberl, M., Odoardi, F., and Flügel, A. (2019). Beta-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration. Nature 566, 503-508.
  • Ballegeer, M., Van Looveren, K., Timmermans, S., Eggermont, M., Vandevyver, S., Thery, F., Dendoncker, K., Souffriau, J., Vandewalle, J., Van Wyngene, L., De Rycke, R., Takahashi, N., Vandenabeele, P., Tuckermann, J., Reichardt, H.M., Impens, F., Beyaert, R., De Bosscher, K., Vandenbroucke, R.E., and Libert, C. (2018). Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice. Journal of Clinical Investigation 128(8), 3265-3279.
  • Klaßen, C., Karabinskaya, A., Dejager, L., Vettorazzi, S., Van Moorleghem, J., Lühder, F., Meijsing, S.H., Tuckermann, J.P., Bohnenberger, H., Libert, C., and Reichardt, H.M. (2017). Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma. Journal of Immunology 199, 48-61 (including cover page).
  • Montes-Cobos, E., Ring, S., Fischer, H.J., Heck, J., Strauß, J., Schwaninger, M., Reichardt, S.D., Feldmann, C., Lühder, F., and Reichardt, H.M. (2017). Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles. Journal of Controlled Release 245, 157-169.