Selected Publications

Braus G, Mösch HU, Vogel K, Hinnen A, Hütter R (1989) Interpathway regulation of the TRP4 gene of yeast. EMBO J. 8, 939-945.

Mösch HU, Graf R, Schmidheini T, Braus G (1990) Two GCN4 responsive elements act synergistically as upstream and as TATA-like elements in the yeast TRP4 promoter. EMBO J. 9, 2951-2957.

Mösch HU, Graf R, Braus GH (1992) Highly sequence-specific initiator elements focus initiation of transcription to distinct sites in the yeast TRP4 promoter. EMBO J. 11, 4583-4590.

Irniger S, Braus GH (1994) Saturation mutagenesis of a polyadenylation signal reveals a hexanucleotide element essential for mRNA 3' end formation in Saccharomyces cerevisiae Proc. Natl. Acad. Sci. USA 91, 257-261.

Künzler M, Braus GH, Georgiev O, Seipel K, Schaffner W (1994) Functional differences between mammalian transcription activation domains at the yeast GAL1 promoter. EMBO J. 13, 641-645.

Xue Y, Lipscomb W N, Graf R, Schnappauf G, Braus G (1994) The crystal structure of allosteric chorismate mutase at 2.2Å resolution. Proc. Natl. Acad. Sci. USA. 91, 10814-10818.

Sträter N, Håkansson K, Schnappauf G, Braus G, Lipscomb WN (1996) Crystal structure of the T-state of yeast chorismate mutase and comparison with the R state. Proc. Natl. Acad. Sci. USA. 93, 3330-3334.

Schnappauf G, Sträter N, Lipscomb WN, Braus GH (1997) A glutamate residue in the catalytic center of the yeast chorismate mutase restricts enzyme activity to acidic conditions. Proc. Natl. Acad. Sci. USA. 94, 8491-8496.

Remacle JE, Albrecht G, Brys R, Braus GH, Huylebroeck D (1997) Three classes of mammalian transcription activation domains stimulate transcription in Schizosaccharomyces pombe. EMBO J. 16, 5722-5729.

Schnappauf G, Lipscomb WN, Braus GH (1998) Separation of inhibition and activation of the allosteric yeast chorismate mutase. Proc. Natl. Acad. Sci. USA. 95, 2868-2873.

Ma J, Zheng X, Schnappauf G, Braus G, Karplus M, Lipscomb WN (1998) Yeast chorismate mutase in the R state: simulations of the active site. Proc. Natl. Acad. Sci. USA. 95, 14640-14645.

Hoffmann B, Wanke C, LaPaglia SK, Braus GH (2000) c-Jun and RACK1 homologs regulate a control point for sexual development in Aspergillus nidulans. Mol. Microbiol. 37, 28-41.

Krappmann S, Lipscomb WN, Braus GH (2000) Coevolution of transcriptional and allosteric regulation at the chorismate metabolic branch point of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 97, 13585-13590.

Taheri N, Köhler T, Braus GH, Mösch HU (2000) Asymmetrically localized Bud8p and Bud9p proteins control yeast cell polarity and development. EMBO J. 19, 6686-6696.

Grundmann O, Mösch HU, Braus GH (2001) Repression of GCN4 mRNA translation by nitrogen starvation in S. cerevisiae. J. Biol. Chem. 276, 25661-25671.

Hoffmann B, Valerius O, Andermann M, Braus GH (2001) Transcriptional autoregulation and inhibition of mRNA translation of the amino acid regulator gene cpcA of the filamentous fungus Aspergillus nidulans. Mol. Biol. Cell. 12, 2846-2857.

Helmstaedt K, Heinrich G, Lipscomb WN, Braus GH (2002) A refined molecular hinge between allosteric and catalytic domain determines allosteric regulation and stability of fungal chorismate mutase. Proc. Natl. Acad. Sci. USA. 10, 6631-6636.

Hartmann M, Schneider TR, Pfeil A, Heinrich G, Lipscomb WN, Braus GH (2003) Evolution of feedback-inhibited beta/alpha barrel isoenzymes by gene duplication and a single mutation. Proc. Natl. Acad. Sci. USA 100, 862-867.

Bolte M, Dieckhoff P, Krause C, Braus GH, Irniger S (2003) Synergistic inhibition of APC/C by glucose and activated Ras proteins is mediated by each of the Tpk1-3 proteins in budding yeast. Microbiology 149, 1205-1216.

Braus GH, Grundmann O, Brückner S, Mösch HU (2003) Amino acid starvation and Gcn4p regulate adhesive growth and FLO11 expression in Saccharomyces cerevisiae. Mol. Biol. Cell. 14, 4272-4284.

Krappmann S, Bignell EM, Reichhard U, Rogers T, Hynes K, Braus GH (2004) The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to virulence of this fungal pathogen. Mol. Microbiol. 52, 785-799.

Helmstaedt K, Strittmatter A, Lipscomb WN, Braus GH (2005) Evolution of DAHP synthase encoding genes in the yeast Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 102, 9784-9789.

Galagan JE, ... Braus GH, Draht O, Busch S, ... Birren B (2005) Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature. 438, 1105-1115.

Bömeke K, Pries R, Korte V, Scholz E, Herzog B, Braus GH (2006) Yeast Gcn4p stabilization is initiated by the dissociation of the nuclear Pho85/Pcl5 complex. Mol. Biol. Cell. 17, 2952-2962.

Busch S, Schwier EU, Nahlik K, Bayram Ö, Draht OW, Helmstaedt K, Krappmann S, Valerius O, Lipscomb WN, Braus GH (2007) An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation. Proc. Natl. Acad. Sci. USA. 104, 8125-8130.

Valerius O, Kleinschmidt M, Rachfall N, Schulze F, Marin SL, Hoppert M, Streckfuss-Bömeke K, Fischer C, Braus GH (2007) The S. cerevisiae homolog of mammalian RACK1, CPC2/ASC1, is required for FLO11 dependent adhesive growth and dimorphism. Mol. Cell. Proteomics. 6, 1968-1979.

Fichtner L, Schulze F, Braus GH (2007) Differential Flo8p dependent regulation of FLO1 and FLO11 for cell-cell and cell substrate adherence of S. cerevisiae S288c. Mol. Microbiol. 66, 1276-1289.

Bayram Ö, Biesemann C, Krappmann S, Galland P, Braus GH (2008) More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development. Mol. Biol. Cell. 19, 3254-3262.

Bayram Ö, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH (2008) VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 320, 1504-1506.

Padmanabhan N, Fichtner L, Dickmanns A, Ficner R, Schulz JB, Braus GH (2009) The Yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress. Mol. Biol. Cell. 20, 68-77.

Karpinar DP, Balija MBG, Kügler S, Opazo F, Rezaei-Ghaleh N, Bender N, Kim HY, Taschenberger G, Falkenburger BH, Heise H, Kumar A, Riedel D, Fichtner L,Voigt A, Braus GH, Giller K, Becker S, Herzig, A, Baldus, M, Jäckle H, Eimer S, Schulz JB, Griesinger C, Zweckstetter M (2009) Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson`s disease models. EMBO J. 28, 3256-3268.

Nahlik K, Dumkow M, Bayram Ö, Helmstaedt K, Busch S, Valerius O, Gerke J, Hoppert M, Schwier E, Opitz L, Westermann M, Grond S, Feussner K, Goebel C, Kaever A, Meinecke P, Feussner I, Braus GH (2010) The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development. Mol. Microb. 78, 962-979.

Sarikaya Bayram Ö, Bayram Ö, Valerius O, Park HS, Irniger S,, Gerke J, Ni M, Han KH, Yu JH, Braus GH (2010) LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity. PLoS Genet. 6, e1001226.

Herzog B, Streckfuss-Bömeke K, Braus GH (2011) A feedback circuit between transcriptional activation and self-destruction of Gcn4 separates its metabolic and morphogenic response in diploid yeasts. J Mol Biol. 405, 909-925.

Helmstaedt K, Schwier EU, Christmann M, Nahlik K, Westermann M, Harting R, Grond S, Busch S, Braus GH (2011) Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylaton site. Mol Biol Cell. 22, 153-164.

Rachfall N, Heinemeyer I, Morgenstern B, Valerius O, Braus GH (2011) 5’TRU: Identification and analysis of translationally regulative 5’ translated regions in amino acid starved yeast cells. Mol. Cell. Proteomics 10, M110.0033350.

Bayram Ö, Braus GH (2012) Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins. FEMS Microbiol. Rev. 36, 1-24 [Journal Cover].

Bayram Ö, Sarikaya Bayram Ö., Ahmed YL, Maruyama J, Valerius O, Rizzoli SO, Ficner R, Irniger S, Braus GH (2012) The A. nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. PLoS Genet. 8, e1002816 [Journal Cover].

Petroi D, Popova B, Taheri-Talesh N, Irniger S, Shahpasandzadeh H, Zweckstetter M, Outeiro TF, Braus GH (2012) Aggregate clearance of alpha-synuclein in S. cerevisiae depends more on autophagosome and vacuole function than on the proteasome. J. Biol. Chem. 287, 27567-27579.

Rachfall N, Bandau S, Ehrenreich A, Valerius O, Braus GH (2013) RACK1/Asc1p, a ribosomal node in cellular signalling. Mol. Cell. Proteomics. 12, 87-105.

Christmann M, Schmaler T, Gordon C, Huang X, Bayram Ö, Schinke J, Stumpf S, Dubiel W, Braus GH (2013). Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome (2013) PLoS Genet. 9, e1003275.

Timpner C, Braus-Stromeyer SA, Tran VT, Braus GH (2013) The Cpc1 regulator of the cross-pathway control of amino acid biosynthesis is required for pathogenicitiy of the vascular pathogen Verticillium longisporum. Mol. Plant Microbe Interact. 26, 1312-1324.

Harting R, Bayram Ö, Laubinger K, Valerius O, Braus GH (2013) Interplay of the fungal sumoylation network for control of multicellular development. Mol Microb. 90, 1125-1145.

Ahmed YL, Gerke J, Park HS, Bayram Ö, Neumann P, Ni M, Dickmanns A, Kim SC, Yu JH#, Braus GH#, Ficner R# (2013) Fungal velvet regulators contain a DNA binding domain reminiscent of NF-kB. PLoS Biol. 11, e1001750 (# corresponding authors).

Tran VT, Braus-Stromeyer SA, Kusch H, Reusche M, Kaever A, Kühn A, Valerius O, Landesfeind M, Aßhauer K, Tech M, Hoff K, Pena TC, Stanke M, Lipka V, Braus, GH (2014) Verticillium transcription activator of adhesion Vta2 suppresses microsclerotia formation and is required for systemic infection of plant roots. New Phytol. 202, 565-581.

Sarikaya-Bayram Ö, Bayram Ö, Feussner L, Kim JH, Kim HS, Kaever A, Feussner I, Chae KS, Han DM, Han KH, Braus GH (2014) Membrane-bound methyltransferase complex VapA-VipC-VapB guides epigenetic control of fungal development. Dev. Cell 29, 406-420. [Journal Cover].

Gerke J, Braus GH (2014) Manipulation of fungal development as source of novel secondary metabolites for biotechnology. Appl. Microbiol. Biotechnol. 98, 8443-8455.

Beckmann EA, Köhler AM, Meister C, Christmann M, Draht O, Rakebrandt N, Valerius O, Braus GH (2015) Integration of the catalytic subunit activates deneddylase activity in vivo as final step in fungal COP9 signalosome assembly. Mol Microb. 97, 110-124.

Lin CJ, Sasse C, Valerius O, Irmer H, Heinekamp T, Straßburger M, Tran VT, Herzog B, Braus-Stromeyer SA, Braus GH (2015) Transcription factor SomA is required for adhesion, development and virulence of the human pathogen Aspergillus fumigatus. PLoS Pathog. 11, e1005205.

Tenreiro S, Rosado-Ramos R, Gerhardt E, Magalhaes F, Popova B, Braus GH, Outeiro TF (2016) Yeast reveals similar mechanisms underlying alpha- and beta- synuclein toxicity. Hum. Mol. Genet. 25, 275-290.

Ertych N, Stolz A, Valerius O, Braus GH, Bastians H (2016) The CHK2-BRCA1 tumor suppressors restrain oncogenic AURORA-A to ensure proper mitotic microtubule assembly. Proc. Natl. Acad. Sci. USA. 113, 1817-1822.

Schinke J, Kolog Gulko M, Christmann M, Valerius O, Stumpf SK, Stirz M, Braus GH (2016) The DenA/DEN1 interacting phosphatase DipA controls septa positioning and phosphorylation-dependent stability of cytoplasmatic DenA/DEN1 during fungal development. PLoS Genet. 12, e1005949.

Kleinknecht A, Popova B, Lázaro DF, Pinho R, Valerius O, Outeiro TF, Braus GH (2016) C-terminal tyrosine residue modifications modulate the protective phosphorylation of serine-129 of α-synuclein in a yeast model of Parkinson´s disease. PLoS Genet. 12, e1006098.

Jöhnk B, Bayram Ö, Abelmann A, Heinekamp T, Mattern D, Brakhage AA, Jacobsen ID, Valerius O, Braus GH (2016) SCF ubiquitin ligase F-box protein Fbx15 controls nuclear co-repressor localization, stress response and virulence of the human pathogen Aspergillus fumigatus. PLoS Pathog. 12, e1005899.

Schmitt K, Smolinski N, Neumann P, Schmaul S, Hofer-Pretz V, Braus GH, Valerius O (2017) Asc1/ RACK1 connects ribosomes to eukaryotic phospho-signaling. Mol. Cell. Biol. 37, e00279-16.

de Vries RP, ... , Bayram Ö, ..., Braus-Stromeyer SA, ..., Braus GH, Grigoriev IV (2017) Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biol. 18, 28.

Shlezinger N, Irmer I, Dhingra S, Beattie SR, Cramer RA, Braus GH, Sharon A, Hohl TM (2017) Sterilizing immunity in the lung relies on targetting fungal apoptosis-like programmed cell death. Science 357, 1037-1041.

Opitz N, Schmitt K, Hofer-Pretz V, Neumann B, Krebber H, Braus GH, Valerius O (2017) Capturing the Asc1p/RACK1 microenvironment at the head region of the 40S ribosome with quantitative BioID. Mol. Cell. Proteomics. 16, 2199-2218.

Kolog Gulko M, Heinrich G, Gross C, Popova B, Valerius O, Neumann P, Ficner R, Braus GH (2018) Sem1 links proteasome stablitiy and specificity to multicellular development. PLoS Genet. 42, e1007141.

Popova P, Kleinknecht A, Arendarski A, Mischke J, Braus GH (2018) Sumoylation protects against β-synuclein toxicity in yeast. Front. Mol. Neurosc. 11, 94.

Riquelme M, Aguirre J, Bartnicki-García S, Braus GH, Feldbrügge M , Fleig U, Hansberg M, Herrera-Estrella A, Kämper J, Kück U, Mouriño-Pérez RR, Takeshita N, Fischer R (2018) Fungal morphogenesis: From the polarized growth of hyphae to complex 
reproduction and infection structures. Microbiol. Mol. Biol. Rev. 82, e00068-17.

Kretschmar FK, Mengel L, Müller AO, Schmitt K, Biersch KF, Valerius O, Braus G, Ischebeck T (2018) PUX10 is a lipid droplet-localized scalffold protein that interacts with CDC48 to facilitate degradation of ubiquitinated proteins. Plant Cell 30, 2137-2160.

Thieme KG, Gerke J, Sasse C, Valerius O, Thieme S, Karimi R, Heinrich AK, Finkgernagel F, Smith K, Bode HB, Freitag M, Ram AFJ, Braus GH (2018) Velvet domain protein VosA represses the zinc cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary metabolism. PLoS Genet. 14, e1007511.

Werner A, Herzog, B, Voigt O, Valerius O, Braus GH, Pöggeler S (2019) NBR1 is involved in selective pexophagy in filamentous ascomycetes and can be functionally replaced by a tagged version of its human homolog. Autophagy 15, 78-90.

Bui TT, Harting R, Braus-Stromeyer SA, Tran VT, Leonard M, Höfer A, Abelmann A, Bakti F, Valerius O, Schlüter R, Stanley CE, Ambrósio A, Braus GH (2019) Verticillium dahliae transcription factors Som1 and Vta3 control microsclerotia formation and sequential steps of plant root penetration and colonisation to induce disease. New Phytol. 221, 2138-2159.

Köhler AM, Harting R, Langeneckert AE, Valerius O, Gerke J, Meister C, Braus GH (2019) Integration of fungal specific CandA-C1 into a trimeric CandA complex allowed splitting of the gene for the conserved receptor exchange factor of CullinA E3 ubiquitin ligases in Aspergilli. mBio 10, e01094-19.

Meister C, Thieme KG, Thieme S, Köhler AM, Schmitt K, Valerius O, Braus GH (2019) COP9 signalosome interaction with UspA/Usp15 deubiquitinase controls VeA mediated fungal multicellular development. Biomolecules 9, 238.

Bardetti P, Castanheira S, Valerius O, Braus GH, Pérez-Martín J (2019) Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus. eLife 8: e48943.

Meyer V, Basenko EY, Benz JP, Braus GH, Caddick MX , Csukai M, de Vries RP, Endy D, Frisvad J, Gunde-Cimerman N, Haarmann T, Hadar Y, Hansen K, Johnson RI, Keller NP, Kraševec N, Mortensen UH, Perez R, Ram AFJ, Record E, Ross P, Shapaval V, Steiniger C, van den Brink H, van Münster J, Yarden O, Wösten HAB (2020) Growing a circular economy with fungal biotechnology: a white paper. Fungal Biol. Biotechnol. 7, 5.

Leonard M, Kühn A, Harting R, Maurus I, Nagel A, Starke J, Kusch H, Valerius O, Feussner K, Feussner I, Kaever, Landesfeind M, Morgenstern B, Becher D, Hecker M, Braus- Stromeyer S.A, Kronstad JW, Braus GH (2020) V. longisporum elicits media-dependent secretome responses with capacity to distinguish between plant-related environments. Front. Microbiol. 11, 1876.

Troppens DM, Köhler AM, Schlüter R, Hoppert M, Gerke J, Braus GH (2020) Hülle cells of Aspergillus nidulans with nuclear storage and developmental backup functions are reminiscent of multipotent stem cells. mBio 11, e01673-20.

de Assis LJ, Silva LP, Liu L, Schmitt K, Valerius O, Braus GH#, Ries LNA#, Goldman GH# (2020) The high osmolarity glycerol mitogen-activated kinase regulates glucose carbon catabolite repression in filamentous fungi. PLoS Genet. 16, e1008996 (# corresponding authors).

Gerke J, Frauendorf H, Schneider D, Wintergoller M, Hofmeister T, Pöhlein A, Zebec Z, Takano E., Scrutton, NS, Braus GH (2020) Production of the fragrance geraniol in peroxisomes of a product-tolerant baker’s yeast. Front. Bioeng. Biotechnol. 8: 582052.

Popova B, Wang D, Pätz C, Akkermann D, Lázaro DF, Galka D, Kolog Gulko M, Bohnsack MT, Möbius W, Bohnsack KE, Outeiro TF, Braus GH (2021) DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization. PLoS Genet. 17: e1009407.

Höfer AM, Harting R, Aßmann NF, Gerke J, Schmitt K, Starke J, Bayram Ö, Tran VT, Valerius O, Braus-Stromeyer SA, Braus GH (2021) The velvet protein Vel1 controls initial plant root colonization and conidia formation for xylem distribution in Verticillium wilt. PLoS Genet. 17: e1009434.

Harting R, Starke J, Kusch H, Pöggeler S, Maurus I, Schlüter R, Landesfeind M, Bulla I, Nowrousian M, de Jonge R, Stahlhut G, Hoff K, Aßhauer KP, Thürmer A, Stanke M, Daniel R, Morgenstern B, Thomma BPHJ, Kronstad JW, Braus-Stromeyer SA, Braus GH (2020) A 20 kb Lineage-Specific genomic region tames virulence in pathogenic amphidiploid Verticillium longisporum. Mol. Plant Pathol. http://doi/10.1111/mpp.13071.